Endocrine Abstracts

Background: Diabetes mellitus (DM) is one of the greatest threats to global health and development of the 21th Century worldwide. In Bulgaria, it affects 9.6% of residents between ages 18-69 and has a profound impact on healthcare, economy and individuals. Diabetes and its complications are major causes of early death in our country - each year 4 125 women and 4 000 men die of diabetes-related complication. Diabetes not only reduces patient’s physical wellbeing but also c...

Congenital hypogonadotropic hypogonadism is characterized by delayed or absent puberty and infertility due to abnormally low levels of gonadotropic hormones and sex steroids. The most common reason for its development is Kallmann syndrome - a rare congenital disorder resulting from impaired migration of GnRH-secreting neurons from the olfactory epithelium to the hypothalamus. It is associated with hyposmia and anosmia. In 1942 Klinefelter described 9 men with gynecomastia, spa...

Objective: To compare kisspeptin levels between different phenotypes of PCOS and to analyze the correlation between kisspeptin and PCOS-related hormonal and metabolic disturbances.Patients and methods: The study included 87 women with PCOS, and a control group of 27 clinically healthy women, corresponding in age and BMI to the patients with PCOS. Circulating levels of luteinizing hormone (LH), follicle-stimulating hormone (FSH), testosterone (T), sex-hor...

Introduction: The aim of the study was to assess the function and immunogenicity of thyroid gland of patients undergoing chronic treatment with the opiate agonist Methadone.Material and methods: Cross-sectional, observational study included patients from 18 to 40 years of age undergoing chronic treatment with Methadone for at least 6 months. A total of 176 participants took part in the study. 140 patients were from five clinical programs in Bulgaria and ...

Background: Women with diabetes mellitus type 1 (DMt1) are known to have a higher prevalence of reproductive disorders, including delayed menarche, menstrual cycle abnormalities and рolycystic ovary syndrome (PCOS)-like phenotype.Objective: To evaluate the menstrual cycle characteristics of women with type 1 diabetes mellitus as well as to compare them with healthy women of reproductive age.Methods and patients: The study inclu...